Sheth RA. A comparison of miconazole nitrate and selenium disulfide as anti-dandruff agents. International Journal of Dermatology. 1983;22(2):123-125.
ABSTRACT
ABSTRACT: The anti‐dandruff efficacy of two shampoos containing 2% miconazole
nitrate and 2.5% selenium disulfide was compared in 15 subjects and eight
subjects, respectively. The antifungal drug, miconazole nitrate, was found to
possess anti‐dandruff activity similar to selenium sulfide, a cytostatic
compound. For evaluation, techniques of clinical grading and the corneocyte
count were used and the latter was found inaccurate. Instead, clinical
assessment by grading the severity, supplemented by cytodiagnosis by smear
examination was found more helpful. The latter helps to evaluate both the
altered pathophysiologic and microbial factors operating in a given case of
dandruff, which is a symptom complex brought about by multiple etiologic
factors.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-4362.1983.tb03330.x/full
SELENIUM
Selenium can help prevent dandruff
Selenium is an important component of cellular antioxidant defenses and may protect against uv radiation induced damage to skin cells
McKenzie RC. Selenium, ultraviolet radiation and the skin. Clinical and Experimental Dermatology. 2000;25(8):631-636.
ABSTRACT
Selenium (Se) is a dietary trace mineral in which there has recently been a
surge of interest, in both the popular and the scientific press, because of
its demonstrated anti‐carcinogenic and anti‐inflammatory properties in humans.
In this short review, I will explain why Se is an important component of
cellular anti‐oxidant defences and review its protective effects against UV
radiation‐induced damage to skin cells. Although little is known about whether
selenium can protect human skin from UV‐induced damage, clinical studies are
underway and the anti‐oxidant may offer considerable benefits.
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2230.2000.00725.x/full
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